GREENSBORO, North Carolina (Reuters) - The wife of the campaign aide who claimed paternity for former presidential candidate John Edwards' baby cried on the witness stand on Monday as she recalled why she let her husband say he was the father of someone else's child.
Cheri Young said Edwards, a former U.S. senator who was seeking the 2008 Democratic presidential nomination, explained that the arrangement was necessary both to keep his campaign alive and to prevent his cancer-stricken wife, Elizabeth, from finding out about the affair.
After the candidate convinced his mistress, Rielle Hunter, and the aide, Andrew Young, to go along with the cover-up, Cheri Young said she felt she had no choice but to follow suit.
"I didn't want the responsibility of knowing that because I didn't go along with this, that because I didn't want to try it, that the campaign would explode and it would be my fault and I would have to live with it," Cheri Young testified.
Her testimony opened the second week of Edwards' federal campaign finance trial in Greensboro, North Carolina.
Prosecutors accuse Edwards, 58, of conspiring with Andrew Young to solicit more than $900,000 in illegal campaign contributions from two wealthy donors as part of a plan to conceal the candidate's pregnant mistress from the media and voters.
Edwards, a former trial attorney who became a two-time presidential candidate and the Democrats' vice presidential nominee in 2004, faces possible prison time if convicted of federal election law violations, including charges of conspiracy, accepting illegal campaign contributions and making false statements.
Andrew Young, the government's lead witness, testified against his former boss for much of last week. On Monday, Young's wife reiterated details from his testimony, acknowledging that she used her maiden name to endorse checks totaling $725,000 from heiress Rachel "Bunny" Mellon and deposited them in the Youngs' personal bank accounts.
Cheri Young said she questioned the legality of the arrangement. Through her husband's job as a fundraiser, she knew there were limits in how much an individual donor could provide to a campaign, she said.
'GET THE MONEY IN'
She said Edwards told her during a phone call that his campaign advisers said the payments were legal, and he ordered her to "get the money in" to assist Hunter.
"We were at a peak point" in the campaign, Young said. "And if I didn't do this to take care of this woman, the campaign was going down."
Edwards' defense says the Youngs used much of the donor money to help build themselves a $1.5 million home in North Carolina. The defense argues that Edwards committed no crime because the payments were of a personal nature to keep Elizabeth Edwards from learning of the affair and not to influence the election.
Prosecutors on Monday showed jurors bank records for the $38,000 in checks the Youngs wrote to Hunter between June and December 2007.
"We gave her a monthly stipend, which was per Mr. Edwards' request," said Cheri Young, her voice often filled with fury and disgust as she described the events that took place years ago.
She said the Youngs also allowed Hunter to live with them in North Carolina after a tabloid alleged that Edwards was having an affair.
They bought her a $26,000 BMW and then paid her $2,700 monthly rent and other expenses once she moved into her own place, Young said.
The Youngs and their three children eventually spent months traveling with Hunter to luxury locations around the country to further shield her from the media, Cheri Young said. Young said she didn't have a choice in where they went or whether she could return home with her children as she wished to do.
While Edwards was still a candidate, "there really weren't any options," she said.
[ [ [['A picture is worth a thousand words', 5]], 'http://news.yahoo.com/why-facebook-bought-instagram-4-theories-160400376.html', '[Related: Why Facebook bought Instagram: 4 theories]', ' ', '630', ' ', ' ', ], [ [['He was in shock and still strapped to his seat', 9]], 'http://contributor.yahoo.com/join/yahoonews_virginiabeach', '[Did you witness the jet crash? Share your story with Yahoo! News]', ' ', '630', ' ', ' ', ], [ [['A JetBlue flight from New York to Las Vegas', 3]], 'http://yhoo.it/GV9zpj', '[Related: View photos of the JetBlue plane in Amarillo]', ' ', '630', ' ', ' ', ], [ [['Dick Clark', 11]], 'http://news.yahoo.com/photos/dick-clark-dies-at-82-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/c/21/c217c61aa2d5872244c08caa13c16ec5.jpeg', '500', ' ', 'Reuters', ], [ [['the 28-year-old neighborhood watchman who shot and killed', 15]], 'http://news.yahoo.com/photos/white-house-stays-out-of-teen-s-killing-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120411/martinzimmermen.jpg', '630', ' ', 'AP', ], [ [['Titanic', 7]], 'http://news.yahoo.com/titanic-anniversary/', ' ', 'http://l.yimg.com/a/p/us/news/editorial/b/4e/b4e5ad9f00b5dfeeec2226d53e173569.jpeg', '550', ' ', ' ', ], [ [['He was in shock and still strapped to his seat', 6]], 'http://news.yahoo.com/photos/navy-jet-crashes-in-virginia-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120406/jet_ap.jpg', '630', ' ', 'AP', ], [ [['xxxxxxxxxxxx', 11]], 'http://news.yahoo.com/photos/russian-grannies-win-bid-to-sing-at-eurovision-1331223625-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/1/56/156d92f2760dcd3e75bcd649a8b85fcf.jpeg', '500', ' ', 'AP', ] ]
[ [ [[' the 28-year-old neighborhood watchman who shot and killed', 4]], '28924649', '0' ], [ [['because I know God protects me', 14], ['Brian Snow was at a nearby credit union', 5]], '28811216', '0' ], [ [['The state news agency RIA-Novosti quoted Rosaviatsiya', 6]], '28805461', '0' ], [ [['measure all but certain to fail in the face of bipartisan', 4]], '28771014', '0' ], [ [['matter what you do in this case', 5]], '28759848', '0' ], [ [['presume laws are constitutional', 7]], '28747556', '0' ], [ [['has destroyed 15 to 25 houses', 7]], '28744868', '0' ], [ [['short answer is yes', 7]], '28746030', '0' ], [ [['opportunity to tell the real story', 7]], '28731764', '0' ], [ [['entirely respectable way to put off the searing constitutional controversy', 7]], '28723797', '0' ], [ [['point of my campaign is that big ideas matter', 9]], '28712293', '0' ], [ [['As the standoff dragged into a second day', 7]], '28687424', '0' ], [ [['French police stepped up the search', 17]], '28667224', '0' ], [ [['Seeking to elevate his candidacy back to a general', 8]], '28660934', '0' ], [ [['The tragic story of Trayvon Martin', 4]], '28647343', '0' ], [ [['Karzai will get a chance soon to express', 8]], '28630306', '0' ], [ [['powerful storms stretching', 8]], '28493546', '0' ], [ [['basic norm that death is private', 6]], '28413590', '0' ], [ [['songwriter also saw a surge in sales for her debut album', 6]], '28413590', '1', 'Watch music videos from Whitney Houston ', 'on Yahoo! Music', 'http://music.yahoo.com' ], [ [['keyword', 99999999999999999999999]], 'videoID', '1', 'overwrite-pre-description', 'overwrite-link-string', 'overwrite-link-url' ] ]
if you ever meet a perfect version of yourself constructed by aliens from radio transmissions, don't shake their hand.
For those who don't know, this refers to a story in the Feynman Lectures on Physics. Here's my version; I've taken some liberties.
Imagine you're on the phone with an alien who speaks English, except they don't know what "left" and "right" mean. You want to explain it to them so they know which tentacle they should use to shake the right-handed President's hand if they should ever meet. The alien can be anywhere in the universe, so you can't refer to stellar positions or similar, leading you to devise an experiment for them to perform.
Your initial attempts use gravity, electricity, and magnets, but you notice each experiment comes out essentially the same if you swap "right" and "left"--for instance, you could give the alien instructions for making a clock in hopes of defining "right" using clockwise rotation, except if the alien made the clock exactly backwards by reversing the notion of "left" and "right", they wouldn't be able to tell. A particle physicist happens by and tells you about a magical experiment involving the weak nuclear force that *does* distinguish left and right inasmuch as the experiment fails if the alien screws up "right" and "left" and succeeds otherwise. (For the curious, some more details here [lbl.gov] and here [wikipedia.org].) Great, problem solved.
"But wait!" the physicist says. "The alien needs to use regular matter instead of antimatter in the experiment. The results will be reversed otherwise! Come to think of it, I have no idea how to tell them the difference between matter and antimatter. If you ever meet them and they start trying to shake your left hand, RUN, since the alien will be made of antimatter!"
The one and only Janice Dickinson has never shied away from airing her grievances about Tyra Banks ? and she has no plans to stop! The self-proclaimed "first supermodel" recently joined the Derek and Romaine show on SiriusXM radio and shared her strong opinions about the news that the majority of America's Next Top Model judges will not be returning.
The recent star of Celebrity Rehab didn't hold back, sharing her dislike for media mogul Tyra. ?She?s one selfish, greedy woman,? Janice said, adding, ?She doesn?t have a creative bone in her body, so someone else is pulling the strings on this one.?
As far as the other judges not returning to the reality competition, the 57-year-old did single out modeling coach Miss J as one whom she praises and adores. But everyone else? ?I don?t like any of them. Fact. And they don?t like me!?
Be sure to check out Derek and Romaine weeknights from 6-10 p.m. ET (3-7 p.m. PT) on SiriusXM OutQ 108 through your SiriusXM Radio.
MANILA (Reuters) - China is likely to be high on the agenda at top level U.S.-Philippine security talks on Monday as Washington refocuses its foreign policy on Asia and Manila realizes its limits in trying to solve territorial disputes with Beijing alone.
China has maritime spats with several countries in the South China Sea, believed to be rich in oil and gas and crossed by important shipping lanes, and its neighbors fear its growing naval reach in staking claims.
Those disputes are pushing the Philippines to seek closer cooperation with the United States, which in turn has prompted China to warn Washington against getting involved, denouncing last week's U.S.-Philippine military drills as bringing the risk of armed conflict closer.
"I'm sure we need to be diplomatic, but I don't think we should tip-toe around the Chinese on this," said Walter Lohman, director of the Asian Studies Center with the conservative Washington-based Heritage Foundation think tank.
"...There is nothing new about the U.S. exercising with the Philippines. We shouldn't refrain because the Chinese don't like it. In fact, I expect the (Washington meeting) will come up with some agreement on increasing the frequency and variety of exercises, ship visits. Also expect agreement on hardware, joint use of Philippines' training facilities and bases."
The talks also coincide with a potential new source of tension between Washington and Beijing after blind activist Chen Guangcheng was reported late last week to have sought U.S. protection in the Chinese capital after an audacious escape from 19 months under house arrest.
On Sunday, China said it had made "stern representations" to the Philippines about its proposal for international arbitration over Scarborough Shoal, site of the most recent stand-off between the two sides.
"China urges the Philippines to earnestly respect China's sovereignty and do nothing to expand or complicate matters," the ministry cited Deng Zhonghua, head of its department of boundary and ocean affairs, as saying.
Manila's moves to strengthen security ties with its former colonial master coincide with the U.S. foreign policy "pivot" towards Asia to concentrate on, among other things, North Korea's nuclear ambitions and China's military buildup.
Twenty years after the Philippines voted to remove American bases, it now wants to give U.S. troops more access to its ports and airfields.
"We enjoy a really close military-to-military relationship with the Philippines and I think certainly coming out of this two plus two, we'll be looking for ways to improve and enhance that relationship," said Pentagon spokesman Navy Captain John Kirby, referring to talks between the defence and foreign secretaries, the highest-level security talks yet between the two sides.
"But it is safe to say that ... our relationship with the Philippines is part and parcel of the larger shift to focus on the Asia-Pacific."
A Philippine general familiar with the discussions to be held in Washington said the United States had a list of airfields in the Philippines that it could use for routine deployment of tankers, fighters and transport planes.
"These are not new bases for the Americans, these are still our facilities," said the general who declined to be identified. "They are only asking us if we can share some of our idle space with them."
Kirby said the United States wanted to continue "a rotational and training" relationship. "We're certainly not looking ... for permanent basing there."
This is nevertheless a sensitive area for Philippine President Benigno Aquino, some of whose political advisers are uncomfortable with an expanding U.S. role.
The U.S. plan to use Philippine airports is not new. At the height of U.S. operations in Iraq and Afghanistan in the mid-2000s, Manila allowed U.S. military planes to refuel at an airport in northernmost Batanes province, close to Taiwan.
"We don't want them back, they create noise when most of us are already asleep," Budget Secretary Florencio "Butch" Abad said of U.S. transport planes landing at night in Basco airport.
Abad is one of Aquino's closest political advisers. Another political adviser told Reuters Aquino would not allow a de facto basing arrangement.
"That's a violation of our constitution," he said.
Philippine foreign and defence officials, however, will use the Washington talks to try to get U.S. backing on its position in the South China Sea, invoking freedom of navigation.
"I think we would want all nations, including the U.S., to make a judgment as to what is happening there (in the South China Sea) and what the implications are to their own security," Foreign Affairs Secretary Albert del Rosario has said.
A retired Philippine flag officer said Washington, which is shuffling and redeploying its forces around Asia, including in Japan and Australia, wanted to rebuild the "air bridge" between Northeast and Southeast Asia.
"They are trying to plug these holes when they left Clark in 1992," he said, referring to a former U.S. air base in the northern Philippines. "They need airfields more than ports because most of their tactical aircraft are based too far from potential hotspots in Southeast Asia."
Richard Jacobson, of Pacific Strategies and Assessments, cautioned both sides against playing the China card, saying he did not see naval standoffs in the South China Sea as dramatic enough to improve U.S.-Philippines relations.
"It appears more likely that any new strategic partnership will evolve gradually over time," Jacobson told Reuters.
(Additional Reporting By Paul Eckert and David Alexander in WASHINGTON, and Ben Blanchard in BEIJING)
Calm down, cinema-goers. It just takes time to "settle in" to the strange new ultra-realistic world of high frame-rates, according to Peter Jackson, who's been responding to audience's rather strong panning of 48fps rough cuts from his upcoming 3D epic, Hobbit. Viewers' main beefs were the surprising appearance of the higher cadence footage, which almost looked like it was shot on video, as well as blemishes on actors and sets which were all-too-visible without the crutch of motion blur. But Jackson insists that the footage lacked special effects and color correction, and that the showing was perhaps too short to judge the frame-rate -- which is why he also says there'll be no 48 fps trailer. He even adds that he's now "very aware of the strobing, the flicker and the artifacts" when he's watching regular 24fps cinema -- so the real struggle for audiences might not be adjusting to the new way, but going back to the old.
We were unable to forward you to the advertisement you clicked on.
The likely cause for this is that your browser, feed reader, or email application is configured to not accept cookies, or your reader may launch an external browser to view links without sharing cookies.
If you're using Internet Explorer, make sure your privacy setting is at medium or below.
Select 'Internet Options' from the 'Tools' menu in your browser window
Click the Privacy tab
Adjust your privacy setting if necessary ?
If you're using a reader that embeds Internet Explorer (examples: Microsoft Outlook, Outlook Express, Feed Demon), you'll also need to select Internet Explorer as your default web browser.
Open Internet Explorer
Select 'Internet Options' from the 'Tools' menu in your browser window
Click the 'Programs' tab and check the box for Internet Explorer to check if it is the default browser and save your change
Close your browser, re-open it, and when prompted, select Internet Explorer as your default
You can then click on an ad in your newsletter and visit the site you wish to view
By Agence France-Presse Saturday, April 28, 2012 16:29 EDT
?
Britain?s military is scouting locations in the capital including residential buildings to station surface-to-air missiles during this summer?s Olympic Games, the?Ministry of Defence?said Saturday.
?Ground-based air defence systems could be deployed as part of a multi-layered air security plan for the Olympics, including fast jets and helicopters, which will protect the skies over?London?during the Games,? a spokesman for the ministry said in a statement.
?Based on military advice we have identified a number of sites and? are talking to local authorities and relevant landowners to help minimise the impact of any temporary deployments,? he said.
The ministry has made no final decision on deployment of missiles, but is evaluating sites alongside police, the statement added.
Britain is mounting its biggest peacetime security operation for the?London Olympics, which start on July 27.
The statement was released after residents of an east London apartment block complained on Twitter of being told of a military and police deployment that might include missiles on top of their building.
Resident Brian Whelan, a journalist, told AFP he had been informed in a leaflet distributed Saturday by the gated private block?s management company of plans to station 10?military personnel?there for two months.
?They?re going to do a dummy run and if it goes well, there will be high-velocity missiles stationed on my building, along with soldiers,? he said.
?It seems like it?s completely written in stone ? there?s been no consultation. They announced it in a way that makes it seem like some kind of prize that I?ve won, to be living on an army base, which is insulting.?
The building in Bow, east London was apparently selected because it has an old watch tower converted into a lift shaft and is a 10-minute walk from the Olympic site, he said.
A security force of more than 40,000, backed by a huge intelligence operation, will guard venues, athletes and the millions of visitors expected to throng the British capital for the Games.
?Lone wolf? terrorist attacks are a major concern for security forces but a range of other threats are also being considered.
In 2005, a day after London was named host city, four homegrown suicide bombers attacked three underground trains and a bus, killing 52 people.
Agence France-Presse
AFP journalists cover wars, conflicts, politics, science, health, the environment, technology, fashion, entertainment, the offbeat, sports and a whole lot more in text, photographs, video, graphics and online.
AVONDALE, La. (AP) ? A first-time PGA Tour winner one weekend, a married man the next.
The spring of 2012 will go down as a memorable time in Jason Dufner's life.
Although it took pair of playoff holes, Dufner finally proved he could hold it together and make a mid-tournament lead stand up, making a birdie on his second extra trip down the par-5 18th hole at the TPC Louisiana to win the Zurich Classic in a playoff with Ernie Els.
"It's always really tough playing on Sundays whether you're in the lead or middle of the pack, and today I was fighting, trying to win an event, and I think I showed myself a good bit out there," said the 35-year-old Dufner, whose wedding is next weekend. "Ernie made a great run at me and it felt like with five or six holes (to go) we were probably going to be battling for the win."
Dufner, whose average score at the cut this season ranks second on the Tour, finished atop the leader board for the first time in 164 career PGA Tour starts.
Now if he can only figure out his honeymoon plans.
"The honeymoon is going to be at The Players Championship," Dufner joked about the event in two weeks at TPC Sawgrass. "They got an island green."
Dufner's fianc?e, Amanda Boyd, wasn't about to complain. Watching from behind the 18th green, she was tearful as Dufner finally made the clutch shots he needed to finish on top.
"It's awesome. He's been so close so many times. I don't feel like it's real," Boyd said. "It will be a good wedding."
Dufner said he was more nervous about his final putt of less than 2 feet than about his impending marriage.
"There's a been a good bit of pressure," Dufner said. "People talking about, 'Why aren't you winning? Why can't you close the deal? ... Friends, family, media, even people in my inner circle. And not in a negative way, but when you're leading tournaments going into weekends and you're finishing 24th, there's going to be some questions."
The win should also stamp out some of the bad memories haunting Dufner since the Masters, when he shared the lead after two rounds but faded to 24th.
Dufner lost playoffs last year to Mark Wilson in the Phoenix Open and Keegan Bradley in the PGA Championship for two of his three career runner-up finishes. He had held five previous leads through two rounds, including twice this year.
Entering the fourth round with a two-shot lead in New Orleans, Dufner shot a 2-under 70, while Els had a 67 to match Dufner for a course-record 19-under 269 total.
Both missed birdie putts within 8 feet in the first playoff, so they went back to the 18th tee for the second extra hole, which Dufner won by hitting the green in two strokes and tapping home a short birdie putt after Els' birdie attempt from the fringe narrowly missed.
The 6-foot-3 Els, who goes by the nickname "The Big Easy," hasn't won on the PGA Tour since the 2010 Arnold Palmer Invitational at Bay Hill, a little more than two years ago.
He did not have a bogey in the final round or the playoff, and could have celebrated his 19th career PGA Tour title in the Big Easy if he could have made a birdie putt of a little less than 6 feet on the first playoff hole.
"It was a nice little charge I made and, you know, nice to catch the leader," Els said. "I had a chance to win the tournament with a 6-footer and missed it, but I made quite a few putts on the back nine to keep myself in it. ... Hit the ball pretty well today ? no bogeys on the final round ? so there's a lot of positives."
On the second playoff hole, Els' tee shot went into a fairway bunker, and his second shot landed 137 yards from the pin. His third shot landed on the fringe, nearly 19 feet from the pin, but he nearly saved birdie from there, his putt missing by 2 inches.
Dufner then made his birdie putt, and in his typically low-key way, briefly raised both arms to acknowledge the cheering crowd before casually walking off the green to accept some congratulatory hugs.
After becoming the seventh player to take his first career PGA Tour triumph in New Orleans since 2002, Dufner called it a "great wedding present" for himself and his bride to be.
"It helps with paying for the wedding, obviously," added Dufner, who earned $1,152,000. "They're a little more expensive than I thought or had imagined. ... It'll be a big celebration not only for our marriage but also for my first victory out on the Tour."
Luke Donald shot a 67 to finish third at 17 under, and move past Rory McIlroy for the No. 1 ranking in the world.
Defending Zurich Classic champ Bubba Watson, playing for the first time since a life-changing win at the Masters over Easter weekend, entered the final round eight shots off the lead. He was unable to mount a charge after bogeys on his first two holes. He wound up tied for 18th at 11 under, a solid outing by most standards, but one of his worst finishes of the year.
"All in all, pretty good week being tired, coming back for the first time after winning the Masters, all this different media attention," Watson said. "It's something you got to get used to. (It) wears on you, tires you out. Somehow I finished ? I'm in the top 20. A lot of guys wished they did that."
Els and Dufner were tied at 19 under after 11 holes. Els made par on each of his final seven holes of regulation. Dufner made par on his final eight, none more difficult than on 16, when he hit into water, but salvaged par with a 44-foot putt.
Els' 17-foot birdie putt on 18 missed by about an inch, opening the door for Dufner to win in regulation if he could birdie the 585-yard hole to cap his fourth round.
While Els was on the practice green preparing for a possible playoff, Dufner chipped on to set up a potential winning putt from 10 1/2 feet.
Although he could not convert, pushing the ball about a foot past the right edge of the hole, he made up for it in the playoff.
"Obviously, I haven't had a great history in playoffs last year," Dufner said. "It kind of enters your mind: 'I'm in another playoff. Am I going to be able to get this done?'"
He won't have to ask himself that question any more.
Jarid2 may break the Polycomb silence Public release date: 30-Apr-2012 [ | E-mail | Share ]
Contact: Gina Kirchweger gxk@stowers.org 816-806-1036 Stowers Institute for Medical Research
Stowers scientists use fruit flies to reveal unknown function of a transcriptional regulator of development and cancer
KANSAS CITY, MOHistorically, fly and human Polycomb proteins were considered textbook exemplars of transcriptional repressors, or proteins that silence the process by which DNA gives rise to new proteins. Now, work by a team of researchers at the Stowers Institute for Medical Research challenges that dogma.
In a cover story in the May 2012 issue of the journal Molecular and Cellular Biology, Stowers Investigator Ali Shilatifard, Ph.D., and his team report that in the fruit fly Drosophila melanogaster a component of the Polycomb repressive complex 2 (PRC2), which is called Jarid2, occasionally activates gene expression.
Polycomb proteins, a group of chromatin-binding factors, were initially found to control how developing fly embryos undergo segmentation. Subsequently, researchers discovered that humans also express a gaggle of proteins resembling fly Polycomb factors and that these proteins have crucially significant roles: under normal conditions PRC2 proteins are required for the differentiation of stem cells, but when overactive, act as oncogenes in lymphoma, breast, and prostate cancer.
"Our approach is to use Drosophila as a model to learn how Polycomb group proteins function in the context of cancer," says Shilatifard, who studies mechanisms underlying leukemia in yeast, fruit flies, and mammalian cells. "In this study, we found that a new component of the PRC2 complex, Jarid2, maintains repression of some genes, but also potentially activates other target genes."
In the usual fly-to-human discovery continuum, the current study represents a species turnaround. While investigators analyzing mammalian stem cells had shown that Jarid2 was an important component of PRC2 in mammals, its activity remained unknown in Drosophila. To determine whether it acted together with Polycomb PRC2 in flies, the Stowers team, led by postdoctoral researcher Hans-Martin Herz, Ph.D., applied a proteomic approach to enumerate every Drosophila protein binding to Jarid2 in fly embryos.
Predictably, they found that fly Jarid2 associates with the same protein suspects as it does in mammals. "Previous mammalian studies reported opposing findings in regard to the role of Jarid2 in the PRC2 complex," says Herz. "Some papers said Jarid2 inhibited PRC2 activity while others claimed Jarid2 activated it."
To settle the issue, the group undertook genome-wide profiling by scanning the entire fruit fly genome to determine where Jarid2 and other members of the PRC2 complex localized on DNA. Overall, the proteins showed similar distribution patterns along chromosomes, hinting that PRC2 complexes containing Jarid2 regulate many of the same genes. However, some genes known to be PRC2 targets showed very little occupancy by Jarid2, an observation that suggested Jarid2 does not share all of the characteristics of a core member of the PRC2 complex.
Combining state-of-the-art genomic approaches with classic fly genetics, the group then defined what Jarid2 actually does molecularly in cells. To do that, they compared gene expression profiles of larvae of two distinct types of genetically manipulated flies: those that lacked only Jarid2 expression and flies that lacked expression of a core PRC2 protein. The rationale was that if Jarid2 and the complex shared the same targets and acted in lockstep, those profiles should be identical.
Two surprising observations emerged from that study. First, in Jarid2 mutant flies, some Jarid2/PRC2 co-bound genes exceeded their normal expression and others were inhibited, the latter suggesting that Jarid2 does not always repress a target. Secondly, the pattern of gene expression observed in the Jarid2 flies differed significantly from that seen in the PRC2 mutants, meaning that whatever Jarid2 does biochemically does not mimic what other PRC2 proteins do.
"Our findings challenge the general idea that PRC2 has only a repressive role," says Herz. "In fact, they suggest that PRC2 and Jarid2 may regulate different genes in specific contexts."
Recent reports implicate Jarid2 in diseases as diverse as multiple sclerosis and schizophrenia. But most significantly for the Shilatifard lab are studies linking both PRC2 and Jarid2 to myeloid cancers such as leukemia. "The theme of our lab is factors that regulate the yin and yang of transcription," says Shilatifard, citing his interest in both of the Polycomb proteins and their polar opposites, the Trithorax activator proteinsinitially characterized in flies and also linked to leukemia. "Our overall goal is to gain insight into both."
###
Also contributing to the study were Man Mohan, Ph.D., Alexander S. Garrett, Caitlynn Miller, David Casto, Ying Zhang, Christopher Seidel, Ph.D., Jeffrey S. Haug, Ph.D., Laurence Florens, Ph.D., Michael P. Washburn, Ph.D., of the Stowers Institute for Medical Research, as well as Masamitsu Yamaguchi, Ph.D., from Kyoto Institute of Technology, and Ramin Shiekhattar, Ph.D., from the Wistar Institute.
Funding for the study came from the Stowers Institute for Medical Research, the National Institutes of Health and The Jane Coffin Childs Memorial Fund for Medical Research.
About the Stowers Institute for Medical Research
The Stowers Institute for Medical Research is a non-profit, basic biomedical research organization dedicated to improving human health by studying the fundamental processes of life. Jim Stowers, founder of American Century Investments, and his wife, Virginia, opened the Institute in 2000. Since then, the Institute has spent over 900 million dollars in pursuit of its mission.
Currently, the Institute is home to over 550 researchers and support personnel; over 20 independent research programs; and more than a dozen technology-development and core facilities.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Jarid2 may break the Polycomb silence Public release date: 30-Apr-2012 [ | E-mail | Share ]
Contact: Gina Kirchweger gxk@stowers.org 816-806-1036 Stowers Institute for Medical Research
Stowers scientists use fruit flies to reveal unknown function of a transcriptional regulator of development and cancer
KANSAS CITY, MOHistorically, fly and human Polycomb proteins were considered textbook exemplars of transcriptional repressors, or proteins that silence the process by which DNA gives rise to new proteins. Now, work by a team of researchers at the Stowers Institute for Medical Research challenges that dogma.
In a cover story in the May 2012 issue of the journal Molecular and Cellular Biology, Stowers Investigator Ali Shilatifard, Ph.D., and his team report that in the fruit fly Drosophila melanogaster a component of the Polycomb repressive complex 2 (PRC2), which is called Jarid2, occasionally activates gene expression.
Polycomb proteins, a group of chromatin-binding factors, were initially found to control how developing fly embryos undergo segmentation. Subsequently, researchers discovered that humans also express a gaggle of proteins resembling fly Polycomb factors and that these proteins have crucially significant roles: under normal conditions PRC2 proteins are required for the differentiation of stem cells, but when overactive, act as oncogenes in lymphoma, breast, and prostate cancer.
"Our approach is to use Drosophila as a model to learn how Polycomb group proteins function in the context of cancer," says Shilatifard, who studies mechanisms underlying leukemia in yeast, fruit flies, and mammalian cells. "In this study, we found that a new component of the PRC2 complex, Jarid2, maintains repression of some genes, but also potentially activates other target genes."
In the usual fly-to-human discovery continuum, the current study represents a species turnaround. While investigators analyzing mammalian stem cells had shown that Jarid2 was an important component of PRC2 in mammals, its activity remained unknown in Drosophila. To determine whether it acted together with Polycomb PRC2 in flies, the Stowers team, led by postdoctoral researcher Hans-Martin Herz, Ph.D., applied a proteomic approach to enumerate every Drosophila protein binding to Jarid2 in fly embryos.
Predictably, they found that fly Jarid2 associates with the same protein suspects as it does in mammals. "Previous mammalian studies reported opposing findings in regard to the role of Jarid2 in the PRC2 complex," says Herz. "Some papers said Jarid2 inhibited PRC2 activity while others claimed Jarid2 activated it."
To settle the issue, the group undertook genome-wide profiling by scanning the entire fruit fly genome to determine where Jarid2 and other members of the PRC2 complex localized on DNA. Overall, the proteins showed similar distribution patterns along chromosomes, hinting that PRC2 complexes containing Jarid2 regulate many of the same genes. However, some genes known to be PRC2 targets showed very little occupancy by Jarid2, an observation that suggested Jarid2 does not share all of the characteristics of a core member of the PRC2 complex.
Combining state-of-the-art genomic approaches with classic fly genetics, the group then defined what Jarid2 actually does molecularly in cells. To do that, they compared gene expression profiles of larvae of two distinct types of genetically manipulated flies: those that lacked only Jarid2 expression and flies that lacked expression of a core PRC2 protein. The rationale was that if Jarid2 and the complex shared the same targets and acted in lockstep, those profiles should be identical.
Two surprising observations emerged from that study. First, in Jarid2 mutant flies, some Jarid2/PRC2 co-bound genes exceeded their normal expression and others were inhibited, the latter suggesting that Jarid2 does not always repress a target. Secondly, the pattern of gene expression observed in the Jarid2 flies differed significantly from that seen in the PRC2 mutants, meaning that whatever Jarid2 does biochemically does not mimic what other PRC2 proteins do.
"Our findings challenge the general idea that PRC2 has only a repressive role," says Herz. "In fact, they suggest that PRC2 and Jarid2 may regulate different genes in specific contexts."
Recent reports implicate Jarid2 in diseases as diverse as multiple sclerosis and schizophrenia. But most significantly for the Shilatifard lab are studies linking both PRC2 and Jarid2 to myeloid cancers such as leukemia. "The theme of our lab is factors that regulate the yin and yang of transcription," says Shilatifard, citing his interest in both of the Polycomb proteins and their polar opposites, the Trithorax activator proteinsinitially characterized in flies and also linked to leukemia. "Our overall goal is to gain insight into both."
###
Also contributing to the study were Man Mohan, Ph.D., Alexander S. Garrett, Caitlynn Miller, David Casto, Ying Zhang, Christopher Seidel, Ph.D., Jeffrey S. Haug, Ph.D., Laurence Florens, Ph.D., Michael P. Washburn, Ph.D., of the Stowers Institute for Medical Research, as well as Masamitsu Yamaguchi, Ph.D., from Kyoto Institute of Technology, and Ramin Shiekhattar, Ph.D., from the Wistar Institute.
Funding for the study came from the Stowers Institute for Medical Research, the National Institutes of Health and The Jane Coffin Childs Memorial Fund for Medical Research.
About the Stowers Institute for Medical Research
The Stowers Institute for Medical Research is a non-profit, basic biomedical research organization dedicated to improving human health by studying the fundamental processes of life. Jim Stowers, founder of American Century Investments, and his wife, Virginia, opened the Institute in 2000. Since then, the Institute has spent over 900 million dollars in pursuit of its mission.
Currently, the Institute is home to over 550 researchers and support personnel; over 20 independent research programs; and more than a dozen technology-development and core facilities.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
HOUSTON & EVERETT, Wash.?(BUSINESS WIRE)?ecom instruments Inc. (subsidiary of ecom instruments GmbH of Assamstadt, Germany) and Intermec, Inc. (NYSE:IN) of Everett, Wash. today announced a new intrinsically safe handheld mobile computer for use in hazardous environments that include oil refineries and drilling platforms, petrochemical, pharmaceutical production, agriculture processing and other explosion-classified environments. The new i.roc Ci70 -Ex is the first product offering resulting from the strategic partnership between Intermec and ecom instruments announced in December 2011. The i.roc Ci70 -Ex will be exclusively sold and distributed by ecom.
?At BP, we believe technology can make a significant impact on the enterprise. We focus on a few technologies with immediate impact that will also benefit long-term business needs. The integration of current and emerging RF communications for large industrial sites could yield greater efficiencies for business operations.?
The i.roc Ci70 -Ex is the latest edition of the award-winning i.roc series of handhelds from ecom and the first to be jointly engineered and developed with Intermec. A new paradigm in intrinsically safe mobile computing, the i.roc Ci70 -Ex offers an unmatched feature set among hazardous environment computers, carries the widest range of explosion-hazardous area approvals worldwide, and is fully compatible with applications originally developed for Intermec 70 series devices operating under Windows Embedded Handheld 6.5.3.
The unique modular concept of the i.roc Ci70 -Ex includes a number of industry-firsts among intrinsically safe mobile computers.
Key features include:
Comprehensive wireless networking capabilities?including WWAN (3G CDMA or UMTS via the Qualcomm Gobi 3000 embedded module), WLAN (IEEE 802.11 a/b/g/n), and Bluetooth 2.1 allow for flexible data exchange even in areas with challenging reception conditions.
Advanced, long-range bar code imaging technology pioneered by Intermec and now adapted for intrinsically safe environments.
Radio Frequency Identification (RFID) capability is achieved through modular design that support a wide range of frequencies, from low to ultra-high LF to UHF and ISO Standard frequencies.
Like other devices built from the 70 series platform, the i.roc Ci70 -Ex is fully compatible with Intermec Development Library tools and applications.
A wide range of peripherals and accessories make the i.roc Ci70 -Ex a truly complete enterprise business solution.
In addition to ecom?s worldwide service support, this device carries global certifications from NEC to ATEX and IECEx. Providing intrinsically safe mobile computing expertise for more than 25 years, the strategic partnership with Intermec leverages more than a 40 year legacy of innovation in rugged enterprise solutions to provide an uncompromising product to meet the demands of the industry?s toughest environments. Combining Intermec?s leadership in rugged mobile computing solutions with ecom?s expertise in hazardous environment computing, this new product is ready to face the most challenging applications.
ecomNewlogo.jpg
?Today?s mission-critical hazardous area operations demand mobile computing solutions without compromising on current industry-leading technologies,? said Rolf Nied, President of ecom instruments. ?Intermec and ecom combined their engineering expertise to integrate these state of the art technologies into this cutting-edge intrinsically safe handheld solution.?
?The i.roc Ci70 -Ex offers a best-in-class answer to the growing demand for specialized communications solutions for use in hazardous environments,? said Earl Thompson, Intermec Senior Vice President, Mobile Solutions Business Unit. ?Already equipped with the various worldwide certifications required for explosive atmospheres, this product offers a rugged, efficient and reliable mobile computing solution to empower enterprises in these critical markets.?
The flexible i.roc Ci70 ?Ex design was influenced to a high degree according to end user requirements and customer needs.
Michael M. Haley, Technology Consultant, BP Chief Technology Office stated, ?At BP, we believe technology can make a significant impact on the enterprise. We focus on a few technologies with immediate impact that will also benefit long-term business needs. The integration of current and emerging RF communications for large industrial sites could yield greater efficiencies for business operations.?
?Explosive environments ? such as those found on oil rigs, in petrochemical plants or in pharmaceutical production facilities ? are among the harshest and most challenging environments in which to operate mobile computing and communications devices. In the i.roc Ci70 -Ex, Intermec, a leading rugged mobile computer vendor, and ecom instruments, a leader in the field of intrinsic safety, have co-developed a uniquely differentiated intrinsically safe rugged handheld computer targeted at these environments. What is especially compelling about this device is that it conforms to all key global certifications ? from NEC to ATEX and IECEx ? making a truly global platform,? David Krebs, VP Mobile & Wireless at VDC Research.
The i.roc Ci70 -Ex is showcased at the Offshore Technology Conference, in ecom instruments booth #4231.
For more information, please visit ecom?s Web Site at: www.ecom-ex.us.
IntermecLogo.jpg
For more information, visit www.intermec.com. To follow more from Intermec, visit Intermec?s Trends & Technology blog or www.twitter.com/intermec.
About ecom instruments
Through the development of intrinsically safe equipment for use in Ex-classified areas, ecom instruments has dramatically shaped this sector over the past 25 years. The company offers a wide range of solutions in its four principal product groups of Mobile Computing, Communication, Measurement & Calibration and Portable Lighting. These are used around the world for various industrial applications in the chemical and petrochemical industry, the oil and natural gas industries as well as in the pharmaceutical, mining, energy and environmental sectors. Today the company is a global market leader in the field of portable explosion-protected equipment.
About Intermec
Intermec Inc. (NYSE:IN) develops and integrates products, services and technologies that identify, track and manage supply chain assets and information. Core technologies include rugged mobile computing and data collection systems, voice solutions that increase business performance, bar code printers, label media, and RFID. The company?s products and services are used by customers in many industries worldwide to improve the productivity, quality and responsiveness of business operations. For more information about Intermec, visit www.intermec.com or call 800-347-2636.
Source: www.nytimes.com --- Saturday, April 28, 2012 Apple serves as a window on how technology giants have taken advantage of tax codes written for an industrial age and ill suited to today?s digital economy. ...
[ [ [['A picture is worth a thousand words', 5]], 'http://news.yahoo.com/why-facebook-bought-instagram-4-theories-160400376.html', '[Related: Why Facebook bought Instagram: 4 theories]', ' ', '630', ' ', ' ', ], [ [['He was in shock and still strapped to his seat', 9]], 'http://contributor.yahoo.com/join/yahoonews_virginiabeach', '[Did you witness the jet crash? Share your story with Yahoo! News]', ' ', '630', ' ', ' ', ], [ [['A JetBlue flight from New York to Las Vegas', 3]], 'http://yhoo.it/GV9zpj', '[Related: View photos of the JetBlue plane in Amarillo]', ' ', '630', ' ', ' ', ], [ [['Dick Clark', 11]], 'http://news.yahoo.com/photos/dick-clark-dies-at-82-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/c/21/c217c61aa2d5872244c08caa13c16ec5.jpeg', '500', ' ', 'Reuters', ], [ [['the 28-year-old neighborhood watchman who shot and killed', 15]], 'http://news.yahoo.com/photos/white-house-stays-out-of-teen-s-killing-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120411/martinzimmermen.jpg', '630', ' ', 'AP', ], [ [['Titanic', 7]], 'http://news.yahoo.com/titanic-anniversary/', ' ', 'http://l.yimg.com/a/p/us/news/editorial/b/4e/b4e5ad9f00b5dfeeec2226d53e173569.jpeg', '550', ' ', ' ', ], [ [['He was in shock and still strapped to his seat', 6]], 'http://news.yahoo.com/photos/navy-jet-crashes-in-virginia-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120406/jet_ap.jpg', '630', ' ', 'AP', ], [ [['xxxxxxxxxxxx', 11]], 'http://news.yahoo.com/photos/russian-grannies-win-bid-to-sing-at-eurovision-1331223625-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/1/56/156d92f2760dcd3e75bcd649a8b85fcf.jpeg', '500', ' ', 'AP', ] ]
[ [ [[' the 28-year-old neighborhood watchman who shot and killed', 4]], '28924649', '0' ], [ [['because I know God protects me', 14], ['Brian Snow was at a nearby credit union', 5]], '28811216', '0' ], [ [['The state news agency RIA-Novosti quoted Rosaviatsiya', 6]], '28805461', '0' ], [ [['measure all but certain to fail in the face of bipartisan', 4]], '28771014', '0' ], [ [['matter what you do in this case', 5]], '28759848', '0' ], [ [['presume laws are constitutional', 7]], '28747556', '0' ], [ [['has destroyed 15 to 25 houses', 7]], '28744868', '0' ], [ [['short answer is yes', 7]], '28746030', '0' ], [ [['opportunity to tell the real story', 7]], '28731764', '0' ], [ [['entirely respectable way to put off the searing constitutional controversy', 7]], '28723797', '0' ], [ [['point of my campaign is that big ideas matter', 9]], '28712293', '0' ], [ [['As the standoff dragged into a second day', 7]], '28687424', '0' ], [ [['French police stepped up the search', 17]], '28667224', '0' ], [ [['Seeking to elevate his candidacy back to a general', 8]], '28660934', '0' ], [ [['The tragic story of Trayvon Martin', 4]], '28647343', '0' ], [ [['Karzai will get a chance soon to express', 8]], '28630306', '0' ], [ [['powerful storms stretching', 8]], '28493546', '0' ], [ [['basic norm that death is private', 6]], '28413590', '0' ], [ [['songwriter also saw a surge in sales for her debut album', 6]], '28413590', '1', 'Watch music videos from Whitney Houston ', 'on Yahoo! Music', 'http://music.yahoo.com' ], [ [['keyword', 99999999999999999999999]], 'videoID', '1', 'overwrite-pre-description', 'overwrite-link-string', 'overwrite-link-url' ] ]
FRANKFURT, Germany (AP) ? Inflation in the 17 countries that use the euro fell to an annual 2.6 percent in April, but was still higher than analysts' expectations and presents a continuing headache for the European Central Bank.
The figure fell from 2.7 percent in March, but remained above the 2.5 percent average forecast.
Inflation has remained stuck well above the European Central Bank's goal of just under 2 percent, a target that it now says won't be reached until early 2013.
The ECB says the rate remains high because of higher oil prices and taxes in some countries and not because of inflationary pressures from the economy.
The stubborn inflation rate is important to the eurozone debt crisis because it discourages the ECB bank from cutting its 1 percent benchmark interest rate. Lower rates can spur growth, but can worsen inflation. ECB President Mario Draghi has stressed that the bank will remain faithful to its mandate under the European Union treaty of fighting inflation as its first priority.
Lack of flexibility on interest rates could become more of an issue as worries increase about the depth of the eurozone's economic downturn. The economy of the 17-country group that uses the euro shrank 0.3 percent in the fourth quarter of last year. Recent economic indicators ? such as a disappointing survey of purchasing managers showing lower economic activity ? have raised fears the dip may be deeper.
European Central Bank data Monday added another downbeat note, as loans to the private sector rose by a meager 0.6 percent in March, another sign of weak economic activity. The ECB has said that its ?1 trillion ($1.32 trillion) injection of emergency loans to commercial banks in December and February have improved financial institutions access to funding ? but that businesses are not asking for loans because of shaky economic prospects.
Gone are the days where just a cash register is all that a retail operation needs.? Contemporary retail operations not only need the most current and compliant point of sale systems available; retail operations also need integrated retail systems that can increase sales, improve profits, and boost productivity.
Integrated retail software solutions can give your business significant benefits:
Increased sales?through automated up-sell and cross-sell suggestions, quick access to product information and availability, and better points and rewards programs
Improved profits?through better inventory management, suggested sale items and clearance options, and reduced overhead through more efficient staffing
Boost productivity?through better automation and more efficient processes that move the inventory to where it will sell, utilize the latest in mobile and web technologies, and better overall supply chain management
Retail software solutions must meet this increased demand for integrated systems without inhibiting the existing business processes.
As part of increased sales, shopper engagement can be improved through retail software solutions.? The more engaged a shopper can become, the better the chances of that shopper increasing the sales transaction, building loyalty, returning for more purchases, and making positive referrals to their friends and family.? Imagine your point of sale system with the ability to ?recognize? repeat customers, make recommendations of products or accessories to up-sell or cross-sell, or offer special incentives?? What if your ecommerce website could also recognize repeat visitors and provide custom offers based on purchase history?? All of these techniques can be facilitated through a robust point of sale system that is fully integrated to customer relationship management and other business systems to make the ability to cultivate shopper engagement much easier.
Loyalty programs work to improve customer experiences and to attract new business. With retail software solutions that incorporate loyalty campaigns and programs into their services, a business can easily provide a variety of options for their customers and potential customers in the form of loyalty incentives.? Loyalty programs can attract new customers, increase the purchases of existing customers, maintain customer retention and also encourage sales of more profitable items.? Integrated retail software solutions can offer loyalty programs that can be customized for a particular store or throughout your entire enterprise.
Multi-channel retailing is an approach that is used by retailers of all sizes.? With integrated retail software solutions, your business can coordinate efforts on the retail store level, at the ecommerce website, with mobile marketing, and more.? Through an integrated approach, all of your multi-channel retail systems will have visibility to inventory availability, pricing, and customer data in order to make sales quickly and seamlessly.? Your customers will be presented with a consistent experience regardless of the channel, and your enterprise will have access to detailed reports that track channel effectiveness.
The retail sector continues to evolve and there are new methods to reach customers, build loyalty, and increase brand awareness and market penetration.? Mobile marketing technology and the use of mobile devices as part of the point of sales experience are becoming even more prevalent.? Social media continues to prove itself as an effective marketing tool to bring traffic to your website and to your retail doorway.? More interactive innovations from television, tablets, iPads, smartphones, and other technologies will bring you closer to your customers in new and exciting ways.? Retail software solutions should be prepared to accept these new innovations and utilize them to benefit your business.
From point of sale to website to mobile device and more, integrated retail software solutions can help to build new customers, grow existing customers, and help sales and profits to increase in order to meet your business goals.
Rejoice, sing, dance, and frolic around a big pile of your beloved Apple products. Throw your arms in the air like you do not possess a care, and hug a small child until it burps out the phrase, ?Think differently.?
Because today is truly a joyous day. Today, you no longer have to tolerate living your iLife on such a short leash. Today, you shall be freed from the bondage of confining and diminutive power chords. Today, you will go forth and charge your Apple accessories nearly an entire room's length away from all those pesky wall sockets.
You only have to tithe a mere $14 to order this 9-foot-long iPad & iPhone charging cable from LiveItNexus, and they?ll even send it directly to your doorstep for free (a $33 value).
Never huddle around another power outlet again, no matter if you?re in an airport, a coffee house, or a nuclear power plant. This sturdy and reliable charging cable can keep your iPads and iPhones fully juiced up and ready to use without you having to stay on top of them, literally and figuratively.
You're almost there! Just follow these easy steps: After your purchase, you will receive a printable voucher with a code via email and in your Half Off Depot account. To redeem this deal, visit www.halfoffdepot.com/redemption. Input your voucher code and confirm your shipping address. You will have 30 days to redeem this offer. Following redemption, please allow 72 hours for details to be sent to the email address provided about personalizing your purchase. Unlimited per person and as gifts. Can redeem right away. Please allow up to 2-4 weeks for processing and delivery after redemption. Taxes and Shipping included. Not valid with any other offers or promotions. No cash back or credit.
There are no reviews for this product at this time.
[ [ [['A picture is worth a thousand words', 5]], 'http://news.yahoo.com/why-facebook-bought-instagram-4-theories-160400376.html', '[Related: Why Facebook bought Instagram: 4 theories]', ' ', '630', ' ', ' ', ], [ [['He was in shock and still strapped to his seat', 9]], 'http://contributor.yahoo.com/join/yahoonews_virginiabeach', '[Did you witness the jet crash? Share your story with Yahoo! News]', ' ', '630', ' ', ' ', ], [ [['A JetBlue flight from New York to Las Vegas', 3]], 'http://yhoo.it/GV9zpj', '[Related: View photos of the JetBlue plane in Amarillo]', ' ', '630', ' ', ' ', ], [ [['Dick Clark', 11]], 'http://news.yahoo.com/photos/dick-clark-dies-at-82-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/c/21/c217c61aa2d5872244c08caa13c16ec5.jpeg', '500', ' ', 'Reuters', ], [ [['the 28-year-old neighborhood watchman who shot and killed', 15]], 'http://news.yahoo.com/photos/white-house-stays-out-of-teen-s-killing-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120411/martinzimmermen.jpg', '630', ' ', 'AP', ], [ [['Titanic', 7]], 'http://news.yahoo.com/titanic-anniversary/', ' ', 'http://l.yimg.com/a/p/us/news/editorial/b/4e/b4e5ad9f00b5dfeeec2226d53e173569.jpeg', '550', ' ', ' ', ], [ [['He was in shock and still strapped to his seat', 6]], 'http://news.yahoo.com/photos/navy-jet-crashes-in-virginia-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120406/jet_ap.jpg', '630', ' ', 'AP', ], [ [['xxxxxxxxxxxx', 11]], 'http://news.yahoo.com/photos/russian-grannies-win-bid-to-sing-at-eurovision-1331223625-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/1/56/156d92f2760dcd3e75bcd649a8b85fcf.jpeg', '500', ' ', 'AP', ] ]
[ [ [[' the 28-year-old neighborhood watchman who shot and killed', 4]], '28924649', '0' ], [ [['because I know God protects me', 14], ['Brian Snow was at a nearby credit union', 5]], '28811216', '0' ], [ [['The state news agency RIA-Novosti quoted Rosaviatsiya', 6]], '28805461', '0' ], [ [['measure all but certain to fail in the face of bipartisan', 4]], '28771014', '0' ], [ [['matter what you do in this case', 5]], '28759848', '0' ], [ [['presume laws are constitutional', 7]], '28747556', '0' ], [ [['has destroyed 15 to 25 houses', 7]], '28744868', '0' ], [ [['short answer is yes', 7]], '28746030', '0' ], [ [['opportunity to tell the real story', 7]], '28731764', '0' ], [ [['entirely respectable way to put off the searing constitutional controversy', 7]], '28723797', '0' ], [ [['point of my campaign is that big ideas matter', 9]], '28712293', '0' ], [ [['As the standoff dragged into a second day', 7]], '28687424', '0' ], [ [['French police stepped up the search', 17]], '28667224', '0' ], [ [['Seeking to elevate his candidacy back to a general', 8]], '28660934', '0' ], [ [['The tragic story of Trayvon Martin', 4]], '28647343', '0' ], [ [['Karzai will get a chance soon to express', 8]], '28630306', '0' ], [ [['powerful storms stretching', 8]], '28493546', '0' ], [ [['basic norm that death is private', 6]], '28413590', '0' ], [ [['songwriter also saw a surge in sales for her debut album', 6]], '28413590', '1', 'Watch music videos from Whitney Houston ', 'on Yahoo! Music', 'http://music.yahoo.com' ], [ [['keyword', 99999999999999999999999]], 'videoID', '1', 'overwrite-pre-description', 'overwrite-link-string', 'overwrite-link-url' ] ]
JERUSALEM (AP) ? Benzion Netanyahu, historian, Zionist activist and influential father of Israeli Prime Minister Benjamin Netanyahu, died Monday in his Jerusalem home, the Israeli leader's office said. He was 102.
Born Benzion Mileikowsky in Warsaw, Poland, Netanyahu was a devout follower of revisionist Zionist leader Zeev Jabotinsky, who advocated Jewish military strength and the establishment of a Jewish state on both sides of the Jordan River. Netanyahu served as his personal aide until Jabotinsky's death in 1940.
He then edited right-wing Jewish publications and earned a Ph.D in history from Dropsie College in Philadelphia. Later, he was a professor of Jewish history and Hebrew literature at the University of Denver and Cornell University, where he served as chairman of the department of Semitic languages and literature.
He was best known in academic circles for his research into the medieval inquisition against the Jews of Spain.
Due to his academic career, his family frequently moved between the United States and Israel.
Netanyahu and his wife, Tzila, had three sons: Yonatan, Benjamin and Ido, all of whom served in the same elite Israeli military commando unit. Yonatan, known as Yoni, commanded the Sayeret Matkal unit and was killed in action during a daring 1976 hostage rescue operation in Entebbe, Uganda.
Following his death, Netanyahu returned to Israel full-time. His middle son Benjamin, nicknamed Bibi, went into politics and was elected prime minister of Israel in 1996 and again in 2009. Iddo, the youngest of the three, is a radiologist and writer.
Netanyahu is believed to have had great influence over his son's politics and openly criticized him when his government made concessions toward the Palestinians.
Several analysts speculated that Benjamin Netanyahu was emotionally unable to sign off on a comprehensive peace deal with Israel's Arabs neighbors as long as his father was still alive, a notion the prime minister dismissed as "psychobabble."
In newspaper interviews late in life, Benzion Netanyahu was forceful in his skepticism of Mideast peace.
"The tendency to conflict is in the essence of the Arab. He is an enemy by essence. His personality won't allow him any compromise or agreement. It doesn't matter what kind of resistance he will meet, what price he will pay. His existence is one of perpetual war," he told the Maariv daily in 2009. "The Arab citizens' goal is to destroy us. They don't deny that they want to destroy us."
A new Nintendo Wii Gaming Console Lot of money Is Definitely A Destination Shop
Article by Stonemelsor
At this stage you might have unquestionably heard about the brand new new xbox game stand, the particular Psp. As opposed to most things that originates previous to it again, all the Nintendo wii game console makes all the online players element of the sport with its brand-new new control process. This The nintendo wii game controller can be a wireless handy remote control which senses routines in 3d. Which remote control smell concept will allow you to eschew the conventional control buttons and additionally a joystick that are the usual intended for gaming systems for many years. Instead, of continuously pushing calls as well as going a continue, you progress your personal arm rest; gesturing, using, putting, and regularly flailing on your path with the gameplay! If you desire to knowledge this particular brand new game stage by yourself it?s not easy to recognize what to buy for you to have all the features you need to experience the Nintendo wii game console go through. For this reason the Wii lot of money is becoming an enticing option.
Acquired by itself, the Wii features a handy remote control , from a technical perspective known as the Wiimote , along with Nunchuk controller; a great analog joystick that connects to your Wiimote employing a very long lead. That Nunchuk even offers the inner accelerometer the fact that the Wiimote has, thus it likewise can perform action stinking as well. The actual Nunchuk is usually to be employed in addition to that Wiimote therefore assists to further improve the video game take up practical experience. Additional, the particular Nintendo wii involves every one of the cords, audio-video cords, and then the sensing watering hole and also holders you need to get started. Most crucial, the particular Nintendo wii gaming console may include Wii system Sports, an activity that permits you to test out your techniques at the green, softball diamond, go-karting alley, fight call, and additionally golf courtroom; this is the wonderful platform to show what your Wii system can perform. Having said that, for you if you want to see all of the Nintendo can do, then you will want much more than principle products, along with Nintendo Wii Package might produce accurately that will.
A Wii Bunch is known as a plan available with distinct retail stores similar to Gamestop, EB Matches, together with Wal-Mart. An ordinary Psp Offer includes each of the fundamentals that serve an interesting Nintendo order, but many beneficial additional items. Such as, the Nintendo Wii Console package bought at Gamestop involves supplemental random access memory, an extra handheld remote control, a an even dozen few weeks product or service renewal approach, and even 5 various other video games; Superstar connected with Zelda: The twilight series Queen, Stress Core: Minute Belief, Pink Metallic, Ponder Best Connections, Super Ape Basketball Blueberry Blitz, not to mention Madden National football league 2007. All the Nintendo Wii Gaming Console Deal from Wal-Mart, in addition to stores, adheres to a similar problematic vein, nonetheless bundled game titles can differ. As an illustration, Wal-Mart offered 5 added online games for their Wii System program, at a cheaper price . that will echoes that a lesser amount of provided online games.
Any Nintendo Wii Console program is a brilliant way to begin and experiencing the enjoyable and even thrill the particular Nintendo wii console has to present. When you are getting a Nintendo wii console being a gift for someone else and you?re not merely a recreation knowledge person, a new Nintendo Wii Gaming Console bundle is a really attractive choice since you can make certain this receiver won?t only have all a appliance they want to perform, they will have an amazing options of activities too. According to where you retail outlet you should find that Nintendo Wii lot of money has become popular supplier and it is at this time not being given. Nevertheless, aware and also thorough procuring that will locate a Psp lot of money deal that can be found research a variety of game titles that matches your needs and budget.
Stone Melsor is famous internet marketer.His new website gives more information about Wii Bundle
Granville Island Brewing's Robson Street Hefeweizen, crafted in Vancouver, received a silver medal at the 2010 World Beer Championships. (Supplied)
Report an error
If I were to tell you that craft brewing in Canada started under a bridge you might get the wrong impression, but it's absolutely true.
In 1984, Granville Island Brewing opened its doors in Vancouver, under the girders of the Granville Bridge. The first beer the company produced was Granville Island Lager, which has remained in its lineup to this day.
The brewery has grown and expanded from that initial brew over the last 28 years in interesting and unexpected ways, going through changes in ownership up until its eventual purchase by Molson Coors subsidiary Creemore Springs in 2009.
The last decade has marked significant expansion with a new, larger brewing facility in Kelowna, B.C., where the majority of Granville Island's beers are now produced. While the original brewery is still there, it's currently used mostly for brewing seasonal and speciality beers. It also hosts three tours daily, enlightening craft beer fans and tourists alike.
The focus on seasonal and specialty beers has become prodigious, more than doubling the number of year-round offerings produced by Granville Island. When I spoke to brewmaster Vern Lambourne, he was in the midst of mashing in a Cascadian Dark Ale, the next of the brewery's limited-release series. Typically, the mash is one of the best times to talk to a brewer, who would otherwise be occupied by staring thoughtfully into the distance while the brew day gets started.
Currently, Granville Island is experimenting with wider distribution interprovincially. Their English Bay Pale Ale, which had previously been available in B.C. and Alberta, launched in Ontario to little critical reception in 2010. Possibly, this was due to the large number of Pale Ales already available in Ontario. The style is a craft brewing staple and one additional example, even if it's a good one, will not grab the market by the lapels and shout "drink me."
This time around the company is bringing one of its seasonal offerings: Robson Street Hefeweizen, which received a silver medal at the 2010 World Beer Championships.
"Most of the flavour comes from the yeast," said Lambourne. There are clove and banana flavours, as are to be expected in a Bavarian wheat beer, but also a subtle hint of orange. It pours a cloudy light orange colour with a fluffy white head. The cloudiness is due to the protein from the substantial amount of wheat used to brew the beer. It hovers between sweet and mildly tart on the palate, with a dry finish.
In terms of pairing with food, it goes well with such brunch dishes as eggs benedict and stands up to foods with a smoky flavour.
"It's especially good with lox," said Lambourne, and spicy Thai food as well. If you were a Bavarian, you might want to try it with weisswurst and sauerkraut.
The arrival of Granville Island's Robson Street Hefeweizen in Ontario signals an interesting willingness to experiment with expansion without resorting to the use of flagship brands. While Granville Island has won several awards for its regular lineup over the last few years, this does not seem to be an attempt to anchor a brand permanently on the shelf in Ontario. It's a summer listing which will be available for a limited time.
This is a good sign because it means that we may see other specialty beers from Granville Island in Ontario in the near future. Their specialties are already available in Alberta, but this is a much larger leap of faith, which adds to what is becoming a far more diverse representation of Canadian beer across the country.
Granville Island is building a bridge instead of just sitting under one.
Jordan St. John writes about beer at Saintjohnswort.ca.
A Second Take on Meeting the Press: From an up-close look at Rachel Maddow's sneakers to an in-depth look at Jon Krakauer's latest book ? it's all fair game in our "Meet the Press: Take Two" web extra. Log on Sundays to see David Gregory's post-show conversations with leading newsmakers, authors and roundtable guests. Videos are available on-demand by 12 p.m. ET on Sundays.
![[ Back to EurekAlert! ]](http://www.eurekalert.org/images/back2e.gif){kind=small}
Public release date: 30-Apr-2012
Share ] 
As part of increased sales, shopper engagement can be improved through retail software solutions.? The more engaged a shopper can become, the better the chances of that shopper increasing the sales transaction, building loyalty, returning for more purchases, and making positive referrals to their friends and family.? Imagine your point of sale system with the ability to ?recognize? repeat customers, make recommendations of products or accessories to up-sell or cross-sell, or offer special incentives?? What if your ecommerce website could also recognize repeat visitors and provide custom offers based on purchase history?? All of these techniques can be facilitated through a robust point of sale system that is fully integrated to customer relationship management and other business systems to make the ability to cultivate shopper engagement much easier.